QT Interval Prolongation: As a Predictor of Hepatorenal Syndrome in Cirrhotic Patients With Acute Variceal Bleeding

Background and Aim: Reduced cardiac contractility due to cirrhotic cardiomyopathy, along with reduced output mean arterial pressure, predisposes renal dysfunction HRS in CLD. Hence, whether QT interval prolongation, a marker of cirrhosis, can predict the development following an episode acute variceal bleeding is aim study. Methods: A prospective cohort study was conducted among 164 patients bleeding. These were grouped into two, those having without HRS. The period 1 year. All evaluated before bleeding, during 6 weeks later. Results: In this 89 (54.2%) had prolonged At baseline, 412.3 ms, which showed significant prolongation time 449.3 reduction baseline at follow up 413.2ms (p <0.001). It further found out that statistically association value >467.5 ms independently predicts sensitivity 58.5% specificity 86.6%. Factors be include ascites, QTc INR, Serum sodium, Liver size USG & MELD score. interval, score &INR independent predictors best cut-off values >467.5ms for >19 &>1.82 INR. Conclusion: Acute causes Cirrhosis, it predictor combination INR aid early detection increased risk developing Bleed-precipitated HRS, thus improving their outcome.